Manchester City captain Vincent Kompany will miss out after picking up a minor calf injury while playing for Belgium.
Right-back Kyle Walker is available after a one-match ban, but Raheem Sterling is suspended as a result of his red card at Bournemouth.
Liverpool’s Philippe Coutinho will not be involved despite featuring for Brazil in World Cup qualifying.
Deadline-day signing Alex Oxlade-Chamberlain is in line for a debut after his £35m transfer from Arsenal.
However, full-back Nathaniel Clyne and midfielder Adam Lallana are both long-term absentees.
The Reds are unbeaten against Manchester City under Jurgen Klopp (W3, D1).
Manchester City’s only win in the last seven Premier League meetings was 3-1 at home in August 2014 (D1, L5).
However, City have lost just one of their past eight Premier League home games against the Reds (W4, D3).
Liverpool have scored in 13 successive games against City in all competitions.
Manchester City have lost one of their past 23 home games in the league (W13, D9).
They are currently on an 11-game unbeaten run, their best under Pep Guardiola (W8, D3).
Sergio Aguero has scored in all five of his Premier League appearances against Liverpool at the Etihad.
Aguero’s next goal will make him the Premier League’s highest non-European goalscorer, overtaking Dwight Yorke’s record of 123 goals.
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Liverpool have lost just once in their last 22 top-flight games against last season’s top seven (W12, D9).
They have also kept clean sheets in six of their last seven Premier League matches.
Sadio Mane could become the fourth Liverpool player to score in five successive Premier League games.
James Milner has never been on the losing side when he has scored in the Premier League (W37, D10).
Venue : City of Manchester Stadium, Manchester
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